The role of nonfasting triglycerides in the development of ischemic stroke was investigated in the Copenhagen City Heart Study, a prospective study involving 13,956 men and women among whom 1,529 developed ischemic stroke. A cross-sectional study also quantified the relationship of nonfasting triglyceride and remnant cholesterol concentrations with ischemic stroke in 9,637 individuals. Incidence of ischemic stroke increased as a function of increasing nonfasting triglycerides (p<0.001). Absolute 10-year risk of ischemic stroke ranged from 2.6% in men younger than 55 years with nonfasting triglyceride levels <1.0 mmol/l to 16.7% in men aged 55 years or older with nonfasting triglyceride levels ≥5.0 mmol/l. Corresponding values in women were 1.9% and 12.2%. In the cross sectional study, men and women with a previous history of ischemic stroke had greater nonfasting triglyceride and remnant cholesterol levels than controls. Results of the study suggest that nonfasting triglyceride and remnant lipoprotein cholesterol concentrations could be considered along with LDL cholesterol in the prediction of cardiovascular events, although these findings will have to be replicated in other studies.
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