Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population.

Description

The ability of the apolipoprotein B/apolipoprotein AI (apo B/apo AI) ratio to predict coronary heart disease (CHD) mortality beyond traditional risk factors was tested in a multi-ethnic representative sample of the US population in the Third National Health and Nutrition Examination Survey mortality study. Apo B, apo AI and cholesterol concentrations were all significantly associated with CHD death. Moreover, the apo B/apo AI and cholesterol/HDL cholesterol ratios were both related to CHD death. However, only apo B and the apo B/apo AI ratio remained significantly associated with CHD death after adjusting for cardiovascular risk factors (smoking, dyslipidemia, hypertension, obesity, diabetes and C-reactive protein).