The relationship between intra-abdominal (visceral) and subcutaneous adipose tissue and inflammatory markers was investigated in a cohort of 382 patients with type 2 diabetes of the CHICAGO study. There were significant associations between intra-abdominal adipose tissue and C-reactive protein (CRP), monocyte chemoattractant protein (MCP), intracellular adhesion molecule-1 (ICAM-1) and plasminogen activator inhibitor-1 (PAI-1). When adjusted for body mass index (BMI), only MCP, ICAM-1, vascular cell adhesion molecule and PAI-1 remained associated with intra-abdominal adiposity. However, BMI was associated with CRP and interleukin-6, even after adjusting for intra-abdominal and subcutaneous adipose tissue. After adjusting for BMI, subcutaneous adipose tissue was not associated with any inflammatory markers. These results suggest that adipose tissue distribution is an important feature of the inflammatory component in type 2 diabetes.
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