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Key Publications August 4, 2009

Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.

JAMA 2009;301:1451-9

Flynn KE, Piña IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP

Description

The beneficial effects of aerobic exercise training on the health status of patients with chronic heart failure (n=2,331) was examined in a multicentre, randomized controlled trial with a mean follow-up of 2.5 years. The Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score improved by 5.21 points in the exercise training group vs. 3.28 points in the usual care group (p<0.001). After 3 months, there was no further significant change in the KCCQ score for both groups, resulting in a greater improvement in the KCCQ score for the exercise group at the end of the follow-up (p<0.001). Although modest, study results demonstrated that exercise training improved patient-reported health status compared with usual care.
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