Performance of the UK Prospective Diabetes Study Risk Engine and the Framingham Risk Equations in Estimating Cardiovascular Disease in the EPIC- Norfolk Cohort.

Description

The purpose of this study was to examine the performance of the UK Prospective Diabetes Study (UKPDS) Risk Engine and the Framingham equations in three populations of the EPIC-Norfolk study (1- individuals with known diabetes, 2- individuals with nondiabetic hyperglycemia (HbA1c ≥6.0%) and 3- individuals with normoglycemia (HbA1c<6.0%). Estimated 10-year cardiovascular disease (CVD) risk in the diabetes group was 33% and 37%, respectively, for the UKPDS and Framingham equations. In the hyperglycemia group, the risks were 31% and 22%, respectively. In the normoglycemia group, the risks were 20% and 14%. The Framingham equations performed better in the hyperglycemia and normoglycemia groups than did the UKPDS Risk Engine, and more patients were classified correctly by Framingham than UKPDS.