In this study, the relationship between body fat distribution and C-reactive protein (CRP) was examined in a healthy non obese population. The proportion of abdominal fat was estimated using the waist-to-hip ratio (WHR) and subjects with (n=350) and without (n=199) a high proportion of abdominal fat were matched for body mass index (BMI) and age. Abdominal adiposity was defined by a WHR ≥0.9 in males and ≥0.85 in females. Results showed that in healthy non obese subjects, CRP was associated with abdominal adiposity independently of BMI values. Thus, the authors suggest that WHR could be used in non obese individuals as a marker of subclinical inflammation or used to select individuals in whom CRP should be measured to further characterize their cardiovascular risk.
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