Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysis.

Description

This study investigated whether the anti-inflammatory effects of statins may be of benefit in heart failure, a condition characterized by inflammation in which the relationship between cholesterol and cardiovascular outcomes is reversed. This retrospective analysis from the CORONA clinical trial revealed that the effect of rosuvastatin in patients with heart failure was different according to baseline hs-C-reactive protein (CRP) concentration. For instance, patients with hs-CRP ≥2.0 mg/l presented better outcomes when treated with rosuvastatin. A prospective randomized trial is therefore needed to confirm this apparent therapeutic effect of statins in patients with heart failure and elevated CRP.