Relation of serum leptin to blood pressure of Japanese in Japan and Japanese-Americans in Hawaii.
Hypertension 2009;54:1416-22
Nakamura Y, Ueshima H, Okuda N, Murakami Y, Miura K, Kita Y, Okamura T, Turin TC, Rodriguez B, Curb JD, Stamler J, International Study of Macro/Micronutrients and Blood Pressure, Japan and Hawaii Research Group
This study examined the role of leptin in obesity-related higher blood pressure (BP) in Japanese Americans living in Hawaii (88 men and 94 women) and Japanese in Japan (123 men and 111 women). Using 2 population samples of common genetic background, diverse lifestyles and with a wide range of body mass index (BMI), the results showed that BMI, systolic BP, diastolic BP increased significantly across quartiles of leptin for both sexes and sites (p<0.01 to 0.02). Additionnal analyses revealed that BMI and log-leptin were significantly and independently related to systolic BP and diastolic BP. Therefore the authors suggest that leptin may be an independent mediator for obesity-related elevations in BP.
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