The aim of this study was to examine the inflammatory gene expression profile of different abdominal adipose tissue depots such as intra-abdominal (visceral) adipose tissue (IAAT), superficial subcutaneous adipose tissue (SAT) and deep SAT measured in 17 apparently healthy women (body mass index: 29.3±5.5 kg/m2). Results showed that IAAT inflammatory gene expression differed from the superficial and deep SAT. Multivariate analysis revealed significantly elevated expression of the CC chemokine receptor 2 (CCR2) and macrophage migration inhibitory factor (MIF) in IAAT making a major contribution to the difference observed between IAAT and SAT. In addition, it appears that both CCR2 and MIF are involved in the development of obesity-associated adipose tissue inflammation. Therefore, these elevated concentrations of MIF and CCR2 in IAAT compared to SAT might contribute to the metabolic dysfunction and macrophage infiltration associated with IAAT. These results suggest that abdominal adipose tissue depots have different inflammatory gene expression profile.
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