Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes.
J Am Coll Cardiol 2010;56:225-33
Rijzewijk LJ, Jonker JT, van der Meer RW, Lubberink M, de Jong HW, Romijn JA, Bax JJ, de Roos A, Heine RJ, Twisk JW, Windhorst AD, Lammertsma AA, Smit JW, Diamant M, Lamb HJ
The objective of this study was to evaluate the association between hepatic triglyceride content and both myocardial function and metabolism in type 2 diabetes. The cohort included 61 type 2 diabetic patients who underwent myocardial perfusion and substrate metabolism measurements by positron emission tomography (PET). Results showed that myocardial glucose uptake was decreased in type 2 diabetic patients with high liver triglyceride content. In addition, plasma fatty acid levels were inversely related to myocardial glucose metabolism. Reduced myocardial perfusion and increased myocardial vascular resistance were also observed in patients with high liver fat content as well as decreased myocardial phosphocreatine/adenosine triphosphate ratio. The same subgroup was also characterized by lower HDL cholesterol, higher plasma triglyceride and C-reactive protein levels as well as lower insulin sensitivity compared with patients with lower liver triglyceride content. These results suggest that hepatic steatosis contributes to cardiac abnormalities associated with type 2 diabetes.
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