This study by Cavusoglu et al. investigated the relationship between plasma adiponectin and left ventricular (LV) systolic function using ventriculography in a broad population of 389 patients undergoing coronary angiography for a variety of indications at a Veterans Affairs Medical Center. Patients were classified into two groups according to LV function as (1) normal or mild LV dysfunction (ejection fraction ≥45%) and (2) moderate to severe LV dysfunction (ejection fraction < 45%). The most important finding of this study was that adiponectin was independently associated with LV systolic function in the entire cohort of patients and that this relationship persisted even after adjusting for a variety of clinically relevant covariates associated with LV dysfunction, such as extent of coronary artery disease or renal function (p=0.0002). Additional analyses also revealed that adiponectin was an independent predictor of moderate to severe LV dysfunction [OR: 1.54, (95% CI, 1.21-1.97; p=0.0005)]. Moreover, when analyses were restricted to patients with and without myocardial infarction (MI), adiponectin remained a strong and independent predictor of LV function in these two groups (p=0.0401 and p=0.0023, for MI and non-MI groups, respectively). Finally, in the non-MI population, adiponectin remained an independent predictor of moderate to severe LV dysfunction [OR: 1.52, (95% CI, 1.15-2.02; p=0.0034)]. This study suggests that plasma adiponectin concentrations are an independent predictor of LV systolic dysfunction in a population of patients referred for coronary angiography.
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