The association between body fat distribution variables and adipokines (adiponectin and resistin) and whether these adipokines mediate the association of abdominal fat depots with the cardiometabolic risk profile were examined in 916 individuals (55% women) of the Framingham Heart Study offspring cohort. There were significant relationships between adiponectin concentrations and intra-abdominal (visceral), subcutaneous, pericardial and intrathoracic fat (except subcutaneous fat in men). There were also significant relationships between resistin levels and the above fat depots (except intra-abdominal fat in men). The addition of intra-abdominal fat to a multivariate model helped explain 10-13% of the variability of adiponectin concentrations (variability of only 2-4% in the model without intra-abdominal fat). For resistin levels, the variability increased from 3-4% to 3-6% when intra-abdominal fat was added to the multivariate model. The relationships of intra-abdominal and subcutaneous fat with cardiometabolic risk factors were not fully explained by adiponectin and resistin concentrations.
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