Changes in the prevalence, treatment and management of diabetes from 1999 to 2006 were quantified as part of the National Health and Nutrition Examination Survey. The prevalence of diabetes increased from 6.5% in 1999 to 2002 to 7.8% in 2003 to 2006 (p<0.05). Such an increase was significant in women, non-Hispanic whites and obese individuals. Among diabetic subjects, the proportion of those who achieved glycemic (HbA1c<7.0%) and LDL (<2.59 mmol/l) targets increased from 43.1% to 57.1% (p<0.05) and from 36.1% to 46.5% (p<0.05), respectively, in the absence of any changes in the pattern of antidiabetic treatment. Overall, the proportion of individuals achieving blood pressure targets did not change. The age-adjusted proportion of individuals achieving all 3 targets increased from 7.0% to 12.2% (p=0.06).