This study was conducted to compare the effects of the consumption of different glycemic load (GL) test foods on changes in metabolic risk markers in overweight subjects. For each test food, there were 2 variants with similar macronutrient and fibre compositions but with different sucrose-flour ratios or carbohydrate source to determine the effects of different glycemic indexes (GIs) and GLs. Nine overweight men and six overweight women underwent a randomized, double-blinded, controlled crossover design with 2 successive periods of 14 weeks each. Results revealed no differences in any markers of metabolic syndrome between the test foods with different GLs and GIs. More specifically, no improvements in fasting insulin or glucose concentrations were reported neither in serum lipoprotein profile nor in proinflammatory or prothrombotic markers. Therefore, these results suggest that the consumption of test foods with a decreased GL did not reduce the cardiometabolic risk of asymptomatic overweight individuals.