This study sought to investigate whether the combination of adiponectin and waist circumference measures could be a good discriminative tool to identify high-risk subjects for clusters of risk factors. For that purpose, 360 middle-aged asymptomatic Chinese men were assessed. Results showed a gradual decrease in adiponectin concentrations from individuals with normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to diabetes. By ROC curve analysis, the authors found that the optimal adiponectin value for predicting diabetes was 5.7 µg/ml with a sensitivity and specificity of 86% and 40%, respectively and a likelihood ratio (LR) of 1.42. Moreover, the waist circumference cutoff value of more than 90 cm had a sensitivity of 54% and specificity of 71% and a LR of 1.83. Combining central obesity and hypoadiponectinemia raised the LR to 2.54 and increased specificity up to 81% but sensitivity remained low at 48.8%. Thus, these findings suggest that the combination of hypoadiponectinemia and waist circumference could be used to discriminate individuals with an increased risk of diabetes in Chinese men.
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