Increases in waist circumference and weight as predictors of type 2 diabetes in individuals with impaired fasting glucose: influence of baseline BMI: data from the DESIR study.

Description

The aim of this study was to evaluate the contribution of increases in waist circumference and weight on the progression to type 2 diabetes among individuals with impaired fasting glucose (IFG). The study cohort included 979 men and women with baseline IFG from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). During 9 years of follow-up, 142 cases of incident diabetes were recorded. Results revealed that an increase in waist circumference was associated with diabetes incidence with a standard odds ratio of 1.79 (95% CI: 1.45-2.21), after controlling for baseline risk factors. Analyses in the subgroup with body mass index (BMI) <25 kg/m2 revealed that an increase in waist circumference was a stronger risk marker for progression to type 2 diabetes (odds ratio=2.40, 95% CI: 1.63-3.52) than weight gain. In addition, the effect was partly independent of insulinemia and the homeostasis model assessment of insulin resistance index. These findings promote the potential value of monitoring and preventing increases in waist circumference over time in individuals with IFG, particularly in those classified as normal weight (BMI<25 kg/m2).