This paper examined the usefulness of 2-hour post-prandial glucose to predict the risk of cardiovascular disease (CVD) and all-cause mortality in a non-diabetic population (n=15 145). During a median follow-up of 6.7 years using a Cox model adjusting for the metabolic syndrome, age, sex, smoking, systolic blood pressure, LDL and HDL cholesterol, it was found that elevated 2-hour post-prandial glucose was associated with an increased risk of CVD (hazard ratio (HR)=1.26) and all-cause mortality (HR=1.10). Adjustment for the presence or absence of the metabolic syndrome maintained the independent association between 2-hour post-prandial glucose and the risk of CVD and all-cause mortality. Thus, the inclusion of 2-hour post-prandial glucose improves the predictive ability to identify non-diabetic individuals at increased cardiovascular death.
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