Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

Description

This study sought to determine whether the effects of 17 previously associated type 2 diabetes gene variants on the risk of impaired glucose regulation or incident type 2 diabetes could be influenced by physical activity. Results of this study, which involved 16,003 Swedish adults, revealed that deteriorations in glucose regulation caused by variants HNF1B and CDKN2A/B loci may be attenuated by physical activity.