The hypertriglyceridemic waist phenotype versus the National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation clinical criteria to identify high-risk men with an altered cardiometabolic risk profile.

Description

In this article, the hypertriglyceridemic waist phenotype (waist circumference ≥90 cm and triglyceride levels ≥2.0 mmol/L) is compared to the National Cholesterol Program-Adult Treatment Panel III (NCEP-ATP III) as well as to the International Diabetes Federation (IDF) clinical criteria to identify white men (n=272) at increased cardiometabolic risk. Prevalence values of men with the NCEP-ATP III criteria, the IDF criteria or the hypertriglyceridemic waist phenotype were 59.2%, 64.0% and 51.1%, respectively. The majority of men with the hypertriglyceridemic waist phenotype also met the NCEP-ATP III (82.7%) or the IDF criteria (89.2%). Men with the hypertriglyceridemic waist phenotype were characterized by small low-density lipoprotein particles, increased apolipoprotein B and insulin levels as well as reduced adiponectin concentration. Similar alterations in cardiometabolic markers were observed in men meeting the NCEP-ATP III and IDF criteria. In conclusion, these results show that these 3 screening approaches are useful to identify individuals with altered cardiometabolic risk profile. However, the hypertriglyceridemic waist phenotype is simpler to use than the two other approaches.