The purpose of this study was to examine the contribution of adiponectin as a predictor of cardiovascular risk in a population-based prospective study of middle-aged men (n=3,885). The results revealed that total adiponectin cannot be used as an independent predictor of CVD events in healthy men after adjusting for conventional and metabolic risk factors. On the other hand, this study reported an inverse and independent cross-sectional association between circulating adiponectin levels and markers of glucose metabolism and insulin sensitivity, independent of age and body mass index. Thus, these findings reinforce the stronger predictive role of adiponectin for diabetes risk rather than cardiovascular risk.
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