Usefulness of hypertriglyceridemic waist phenotype in type 2 diabetes mellitus to predict the presence of coronary artery disease as assessed by computed tomographic coronary angiography.

Description

The objective of this study was to examine the efficacy of the hypertriglyceridemic waist phenotype to predict the presence of coronary artery disease (CAD) as assessed by multidetector computed tomographic coronary angiography (CTA) in patients with type 2 diabetes. The study population included 202 diabetic patients (120 men and 82 women, mean age 54±11 years) who were asymptomatic for CAD. Patients were divided into 4 groups on the basis of threshold values for waist circumference measurements (≤88 or >88 cm for women and ≤102 or >102 cm for men) and triglyceride levels (<1.7 or ≥1.7 mmol/L for men and women). Results showed that patients with the hypertriglyceridemic waist phenotype had a deteriorated lipoprotein-lipid profile characterized by increased triglycerides, total cholesterol and LDL cholesterol levels and decreased HDL cholesterol concentrations. Moreover, the group with the hypertriglyceridemic waist phenotype had a deteriorated inflammatory profile as well as presence of CAD measured by CTA which revealed an increase in noncalcified and mixed plaque burden. Thus, these results suggest that the presence of the hypertriglyceridemic waist phenotype is a good marker of a dysmetabolic profile and could be helpful to identify patients with type 2 diabetes at increased cardiovascular risk.