Dr. Jean-Pierre Després, Dr. Peter Libby and Dr. Richard Nesto begin this round table by talking about inflammation, type 2 diabetes and cardiovascular disease. Dr. Libby emphasizes the notion that the issue of inflammation has made progress and allows to refine patient’s clinical evaluation. Dr. Nesto talks about his concern that in the next 20 years there will be a high increase in cardiovascular disease manifestations at an earlier age than ever before. Dr. Després follows by talking about the lifestyle modification messages given to individuals that have been at times misleading. Drs. Libby and Nesto elaborate further this point by saying that the general public has been misinformed about adopting low-fat diets as an answer to prevent cardiometabolic risk which has contributed to a phenomenon of confusion. The panel follows by emphasizing the notion that exercise/physical activity is important in managing cardiometabolic risk even in the absence of weight loss or improvement of glucose tolerance. Finally, Dr. Després concludes this round table by suggesting that reshaping our nutritional habits and adopting a healthy physically active lifestyle are key factors to achieving cardiometabolic health.