CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity, and enhanced leptin sensitivity.

Int J Obes Relat Metab Disord. 2004;28:640-8

Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P

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In this paper, the authors documented the resistance of CB1 receptor knockout mice to diet-induced obesity, which was the first indication of the critical role of endocannabinoids in the development of this form of obesity.

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity, and enhanced leptin sensitivity.

Int J Obes Relat Metab Disord. 2004;28:640-8

Description

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