Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors.

Description

In a prospective study of 8,291 Italian patients who experienced a myocardial infarction within the previous 3 months and were free of diabetes at baseline, investigators examined the incidence of diabetes and impaired fasting glucose (IFG) during a mean follow-up of 3.2 years. The study also assessed the independent demographic, clinical, and lifestyle risk factors related to the development of diabetes. During the study, 12% of patients developed diabetes and 62% developed new-onset IFG (≥5.6 mmol/l) or diabetes. Among independent risk factors for the development of new-onset IFG or diabetes were older age, hypertension, use of beta-blockers, use of lipid-lowering medications (protective), and diuretic use. Moreover, higher BMI, greater BMI gain, current smoking, a lower Mediterranean dietary score (poorer diet), and increased wine consumption (>1 l/day) were also independent lifestyle risk factors. These findings have identified some lifestyle risk factors that could be targeted to reduce the risk of diabetes in high-risk patients with documented coronary artery disease.