This study investigated systemic and adipose tissue nonesterified fatty acid (NEFA) metabolism in 20 insulin-resistant overweight men (body mass index 25-35 kg/m2). For that purpose, groups with either low or high fasting insulin concentrations were compared. The authors found that systemic NEFA concentrations were not elevated in insulin-resistant men compared to controls and that NEFA release was lower in the insulin-resistant men. Based on the results, Bickerton et al. suggested that NEFA release from subcutaneous adipose tissue tended to be suppressed by the elevated insulin concentrations in the insulin-resistant men.
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