Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses.

Description

In this cross-sectional study involving 9 obese men and 8 obese women, the objective was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates. Subjects underwent two protocols involving ingestion of mixed nutrient meals with either glucose-sweetened or fructose-sweetened beverages. Fructose consumption was associated with lower areas under the curve for insulin and leptin levels but higher areas under the curve for triglyceride and lactate concentrations. Among insulin resistant individuals, fructose consumption was associated with higher triglyceride levels during the 24-hour test.