This animal study was performed to examine whether insulin resistance induced by a high-fat diet (HFD) would simulate lipid infusion studies in which injected insulin was not detected in lymph. Following physiological insulin resistance induced by feeding an HFD for 14 weeks, insulin injected directly into the muscle was not detectable in lymph, and glucose uptake was prevented in response to the injection compared to lean animals. These results add evidence that the cellular insulin resistance caused by an HFD occurs because myocytes are not exposed to insulin. Additional studies are required to understand the physiological mechanisms underlying these results.
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