The aim of this study was to examine the correlation between consumption of added sugars and lipid variables among US adults. The study cohort included 6,113 adult participants (3,088 women, 3,025 men) of the National Health and Nutrition Examination Survey (NHANES) 1999-2006. The results indicated that an increased consumption of added sugars was associated with alterations in important cardiovascular disease risk factors such as lower HDL cholesterol levels, higher triglyceride levels, and a higher triglycerides/HDL cholesterol ratio. The authors suggest that the dysmetabolic effects of carbohydrates could be largely mediated by fructose which has been shown to increase de novo lipogenesis in the liver, hepatic triglyceride synthesis, and secretion of VLDL. These data support the importance of reducing the consumption of added sugar.
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