The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp.

Description

The aim of this study was to evaluate the sensitivity and specificity of the fasting triglyceride and glucose (TyG) index to identify insulin resistance compared with the euglycemic-hyperinsulinemic clamp test. The cohort included 11 nonobese healthy subjects, 34 obese normal glucose tolerance individuals, 22 subjects with prediabetes, and 32 diabetic patients. Analyses revealed that TyG index had high sensitivity and specificity to recognize insulin resistance. Moreover, the TyG index is accessible in all clinical laboratories since it is derived from measurements in the fasting state [Ln(fasting triglycerides)(mg/dl)xfasting glucose (mg/dl)/2]. Correlation between the TyG index and total glucose metabolism (M) rates was similar between men (-0.74) and women (-0.73), nonobese (-0.71) and obese (-0.71), and nondiabetic (-0.67) and diabetic (-0.69) individuals. Results also showed that the TyG index was similar to the glucose clamp technique as well as to the homeostasis model assessment of insulin resistance in the evaluation of insulin sensitivity. Thus, these results suggest that this simple and accessible tool is accurate for estimating insulin resistance in high-risk individuals.