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Expert Opinions April 11, 2018

What is the most important risk factor for type 2 diabetes?

Gillian Booth, MD, MSc, FRCPC, Associate Professor, Department of Medicine, University of Toronto; Adjunct Scientist, Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Abdominal Obesity/Body Fat Distribution Diabetes Obesity
Key Publications April 10, 2018

Current pharmacotherapy for obesity.

Nat Rev Endocrinol. 2018;14:12-24

Srivastava G, Apovian CM.
Clinical Trials Obesity Weight Loss
Key Publications April 9, 2018

Obesity: Trends in underweight and obesity - scale of the problem.

Nat Rev Endocrinol. 2018;14:5-6

Yanovski JA
Childhood Obesity Epidemiology Obesity
Key Publications April 9, 2018

Sedentary behavior and compensatory mechanisms in response to different doses of exercise-a randomized controlled trial in overweight and obese adults.

Eur J Clin Nutr. 2017;71:1393-1398

Castro EA, Júdice PB, Silva AM, Teixeira PJ, Benito PJ
Clinical Trials Obesity Physical Activity/Exercise
Key Publications April 6, 2018

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48170 UK Biobank participants.

Int J Obes (Lond). 2017;41:1761-1768

Celis-Morales CA, Lyall DM, Gray SR, Steell L, Anderson J, Iliodromiti S, Welsh P, Guo Y, Petermann F, Mackay DF, Bailey MES, Pell JP, Gill JMR, Sattar N
Genetics Nutrition Obesity
Key Publications April 6, 2018

Objectively measured sedentary time and physical activity and associations with body weight gain: does body weight determine a decline in moderate and vigorous intensity physical activity?

Int J Obes (Lond). 2017;41:1769-1774

Ekelund U, Kolle E, Steene-Johannessen J, Dalene KE, Nilsen AKO, Anderssen SA, Hansen BH
Obesity Physical Activity/Exercise Weight Loss
Key Publications April 5, 2018

Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype.

Int J Obes (Lond). 2017;41:1728-1736

Lefai E, Blanc S, Momken I, Antoun E, Chery I, Zahariev A, Gabert L, Bergouignan A, Simon C
Adipose Tissue Obesity Physical Activity/Exercise
Key Publications March 21, 2018

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease.

Hepatology. 2018;67:123-133

Estes C, Razavi H, Loomba R, Younossi Z, Sanyal AJ
Diabetes Ectopic Fat Obesity
Key Publications March 21, 2018

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.

Hepatology. 2018;67:328-357

Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ
Ectopic Fat Lipids/Lipoproteins Obesity
Key Publications March 20, 2018

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults.

Lancet. 2017;390:2627-2642

NCD Risk Factor Collaboration (NCD-RisC)
Age Epidemiology Obesity
Key Publications March 20, 2018

The future role of the United States in global health: Emphasis on cardiovascular disease.

J Am Coll Cardiol. 2017;70:3140-3156

Fuster V, Frazer J, Snair M, Vedanthan R, Dzau V, Committee on Global Health and the Future of the United States: A Report of the National Academies of Sciences, Engineering and Medicine
Cardiovascular Disease Obesity Prevention
Key Publications March 19, 2018

Sex differences in mechanisms of hypertension associated with obesity.

Hypertension. 2018;71:15-21

Faulkner JL, Belin de Chantemèle EJ
Hypertension Obesity Sex Differences
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