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International Chair on Cardiometabolic Risk
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Key Publications April 20, 2022

Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.

Eur Heart J. 2021;42:3349-3357

Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK
Cardiovascular Disease Epidemiology Genetics
Key Publications April 19, 2022

Polygenic risk score and coronary artery disease: A meta-analysis of 979,286 participant data.

Atherosclerosis. 2021;333:48-55

Agbaedeng TA, Noubiap JJ, Mofo Mato EP, Chew DP, Figtree GA, Said MA, van der Harst P
Cardiovascular Disease Epidemiology Genetics
Key Publications April 1, 2022

Impact of the Apolipoprotein E ε4 allele on the relationship between healthy lifestyle and cognitive decline: A population-based study.

Am J Epidemiol. 2021;190:1225-1233

Dhana K, Aggarwal NT, Rajan KB, Barnes LL, Evans DA, Morris MC
Brain Health Genetics Physical Activity/Exercise
Key Publications March 30, 2022

Causal effect of adiposity measures on blood pressure traits in 2 urban Swedish cohorts: A Mendelian randomization study.

J Am Heart Assoc. 2021;10:e020405

Giontella A, Lotta LA, Overton JD, Baras A; Regeneron Genetics Center, Minuz P, Melander O, Gill D, Fava C
Abdominal Obesity/Body Fat Distribution Genetics Hypertension
Key Publications March 30, 2022

Heart healthy cities: genetics loads the gun but the environment pulls the trigger.

Eur Heart J. 2021;42:2422-2438

Münzel T, Sørensen M, Lelieveld J, Hahad O, Al-Kindi S, Nieuwenhuijsen M, Giles-Corti B, Daiber A, Rajagopalan S
Cardiovascular Disease Genetics Prevention
Key Publications March 25, 2022

Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study.

Atherosclerosis. 2021;329:22-29

van Dam-Nolen DHK, van Dijk AC, Crombag GAJC, Lucci C, Kooi ME, Hendrikse J, Nederkoorn PJ, Daemen MJAP, van der Steen AFW, Koudstaal PJ, Kronenberg F, Roeters van Lennep JE, Mulder MT, van der Lugt A
Cardiovascular Disease Genetics Lipids/Lipoproteins
Key Publications March 23, 2022

Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants.

Am J Clin Nutr. 2021;114:175-184

Zhang H, Greenwood DC, Risch HA, Bunce D, Hardie LJ, Cade JE.
Brain Health Genetics Nutrition
Key Publications March 18, 2022

Associations among adipose tissue immunology, inflammation, exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease.

Gastroenterology. 2021;161:968-981

Fuchs A, Samovski D, Smith GI, Cifarelli V, Farabi SS, Yoshino J, Pietka T, Chang SW, Ghosh S, Myckatyn TM, Klein S
Adipose Tissue Genetics Prevention
Key Publications March 18, 2022

Risk prediction using polygenic risk scores for prevention of stroke and other cardiovascular diseases.

Stroke. 2021;52:2983-2991

Abraham G, Rutten-Jacobs L, Inouye M
Cardiovascular Disease Genetics Prevention
Key Publications March 15, 2022

Sugar-sweetened beverage consumption may modify associations between genetic variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) locus and HDL-C (High-Density Lipoprotein Cholesterol) and triglyceride concentrations.

Circ Genom Precis Med. 2021;14:e003288

Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Pitkänen N et al.
Genetics Lipids/Lipoproteins Nutrition
Key Publications March 14, 2022

Sex-specific associations of genetically predicted circulating Lp(a) (lipoprotein(a)) and hepatic LPA gene expression levels with cardiovascular outcomes: Mendelian randomization and observational analyses.

Circ Genom Precis Med. 2021;14:e003271

Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ
Cardiovascular Disease Genetics Lipids/Lipoproteins
Key Publications March 10, 2022

Genetic evidence for different adiposity phenotypes and their opposing influences on ectopic fat and risk of cardiometabolic disease.

Diabetes. 2021;70:1843-1856

Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, Bell JD, Thomas EL, Yaghootkar H
Cardiometabolic Risk Ectopic Fat Genetics
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