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Page 8 of 9
Key Publications October 13, 2009

Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs.

Am J Physiol Endocrinol Metab 2009;296:E1311-8

Richey JM, Woolcott OO, Stefanovski D, Harrison LN, Zheng D, Lottati M, Hsu IR, Kim SP, Kabir M, Catalano KJ, Chiu JD, Ionut V, Kolka C, Mooradian V, Bergman RN
Abdominal Obesity/Body Fat Distribution Metabolism: Animal Studies
Slide Library December 19, 2008

Role of the dysregulated endocannabinoid system in determining cardiometabolic risk

Vincenzo Di Marzo, PhD, Istituto di Chimica Biomolecolare Pozzuoli, NA, Italy
Metabolism: Animal Studies Metabolism: Human Studies Obesity
Key Publications December 15, 2008

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

Diabetes 2008;57:2977-91

Nogueiras R, Veyrat-Durebex C, Suchanek PM
Metabolism: Animal Studies
Key Publications October 28, 2008

Reversal of visceral adiposity in candy-diet fed female Wistar rats by the CB1 receptor antagonist rimonabant.

Int J Obes (Lond) 2008;32:1363-72

Herling AW, Kilp S, Juretschke HP, Neumann-Haefelin C, Gerl M, Kramer W
Metabolism: Animal Studies
Key Publications September 20, 2008

Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.

Diabetes 2008;57:1999-2011

Dallaire P, Bellmann K, Laplante M et al.
Metabolism: Animal Studies
Key Publications September 16, 2008

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice.

J Lipid Res 2008;49:1658-69

Peterson SJ, Drummond G, Kim DH et al.
Metabolism: Animal Studies
Key Publications August 24, 2008

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

J Clin Invest. 2008;118:2640-50

Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS
Metabolism: Animal Studies
Key Publications July 10, 2008

Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance.

Diabetes 2008;57:1526-35

Li M, Kim DH, Tsenovoy PL et al.
Metabolism: Animal Studies
Key Publications June 18, 2008

Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin.

Circulation 2008;117:2515-22

de Haan W, de Vries-van der Weij J, van der Hoorn JW et al.
Metabolism: Animal Studies
Key Publications May 28, 2008

Effect of apolipoprotein A-V on plasma triglyceride, lipoprotein size, and composition in genetically engineered mice.

J Lipid Res 2008;49:572-80

Nelbach L, Shu X, Konrad RJ, Ryan RO, Forte TM
Metabolism: Animal Studies
Key Publications May 25, 2008

Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling.

Arterioscler Thromb Vasc Biol 2008;28:899-905

Xu SQ, Mahadev K, Wu X et al.
Metabolism: Animal Studies
Key Publications May 5, 2008

Energy restriction enhances therapeutic efficacy of the PPARgamma agonist, rosiglitazone, through regulation of visceral fat gene expression.

Diabetes Obes Metab 2008;10:251-63

Moore GB, Pickavance LC, Briscoe CP, Clapham JC, Buckingham RE, Wilding JP
Metabolism: Animal Studies
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