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Key Publications March 19, 2008

Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo.

J Lipid Res 2008;49:386-93

Hu W, Abe-Dohmae S, Tsujita M et al.
Metabolism: Animal Studies
Key Publications February 11, 2008

Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase.

Circulation 2007;116:2809-17

Shinmura K, Tamaki K, Saito K, Nakano Y, Tobe T, Bolli R
Metabolism: Animal Studies
Key Publications August 30, 2007

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity, and enhanced leptin sensitivity.

Int J Obes Relat Metab Disord. 2004;28:640-8

Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P
Adipokines Metabolism: Animal Studies Obesity
Key Publications August 30, 2007

Leptin-regulated endocannabinoids are involved in maintaining food intake.

Nature 2001;410:822-25

Di Marzo V, Goparaju SK, Wang L et al.
Adipokines Metabolism: Animal Studies Weight Loss
Key Publications August 30, 2007

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

J Clin Invest 2003;112:423-31

Cota D, Marsicano G, Tschop M et al.
Adipose Tissue Metabolism: Animal Studies Weight Loss
Key Publications August 30, 2007

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.

J Clin Invest 2005;115:1298-305

Osei-Hyiaman D, DePetrillo M, Pacher P et al.
Lipids/Lipoproteins Metabolism: Animal Studies Obesity
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