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International Chair on Cardiometabolic Risk
My Healthy Waist

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Key Publications June 22, 2011

Genetic predisposition to obesity leads to increased risk of type 2 diabetes.

Diabetologia 2011;54:776-82

Li S, Zhao JH, Luan J, Langenberg C, Luben RN, Khaw KT, Wareham NJ, Loos RJ
Diabetes Genetics Obesity
Key Publications June 19, 2011

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.

J Clin Endocrinol Metab 2011;96:775-81

Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM, Houmard JA
Genetics Nutrition Obesity
Key Publications June 16, 2011

The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women.

Am Heart J 2010;160:1163-9

Ahmad T, Chasman DI, Mora S, Paré G, Cook NR, Buring JE, Ridker PM, Lee IM
Genetics Physical Activity/Exercise
Key Publications June 14, 2011

Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone.

Diabetes Care 2011;34:730-3

Sacks HS, Fain JN, Cheema P, Bahouth SW, Garrett E, Wolf RY, Wolford D, Samaha J
Diabetes Genetics Inflammation
Key Publications June 13, 2011

Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women.

Diabetes Care 2011;34:675-80

Ahmad T, Lee IM, Paré G, Chasman DI, Rose L, Ridker PM, Mora S
Genetics Nutrition Physical Activity/Exercise
Key Publications June 11, 2011

Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism.

J Intern Med 2011;269:333-9

Pramfalk C, Parini P, Gustafsson U, Sahlin S, Eriksson M
Ectopic Fat Genetics Lipids/Lipoproteins
Key Publications June 10, 2011

Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.

J Intern Med 2011;269:322-32

Luotola K, Pietilä A, Zeller T, Moilanen L, Kähönen M, Nieminen MS, Kesäniemi YA, Blankenberg S, Jula A, Perola M, Salomaa V, Health 2000 and FINRISK97 Studies
Diabetes Genetics Inflammation
Key Publications June 9, 2011

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

BMJ 2011;342:d548

C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, Shah T, Engert JC, Clarke R, Davey-Smith G, Nordestgaard BG, Saleheen D, Samani NJ, Sandhu M, Anand S, Pepys MB, Smeeth L, Whittaker J, Casas JP, Thompson SG, Hingorani AD, Danesh J
Genetics Inflammation
Key Publications June 7, 2011

A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.

Eur Heart J 2011;32:469-75

Versmissen J, Oosterveer DM, Yazdanpanah M, Mulder M, Dehghan A, Defesche JC, Kastelein JJ, Sijbrands EJ
Genetics Lipids/Lipoproteins
Key Publications June 6, 2011

Parental history and myocardial infarction risk across the world: the INTERHEART Study.

J Am Coll Cardiol 2011;57:619-27

Chow CK, Islam S, Bautista L, Rumboldt Z, Yusufali A, Xie C, Anand SS, Engert JC, Rangarajan S, Yusuf S
Genetics
Key Publications June 4, 2011

Life-course socioeconomic position and type 2 diabetes mellitus: The Framingham Offspring Study.

Am J Epidemiol 2011;173:438-47

Smith BT, Lynch JW, Fox CS, Harper S, Abrahamowicz M, Almeida ND, Loucks EB
Diabetes Genetics
Key Publications May 31, 2011

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men.

J Lipid Res 2011;52:558-65

Tremblay AJ, Lamarche B, Lemelin V, Hoos L, Benjannet S, Seidah NG, Davis HR Jr, Couture P
Genetics Lipids/Lipoproteins Metabolism: Human Studies
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