The present study was designed to investigate the effects of acute hypertriglyceridemia induced by Intralipid infusion on the anti-inflammatory capacity of HDL particles. Triglyceride and HDL triglyceride concentrations increased significantly after Intralipid infusion. Following the infusion of Intralipid, HDL particles had a significantly reduced anti-inflammatory activity compared to controls. Finally, there were significant relationships between HDL triglyceride levels and vascular cell adhesion molecule-1 expression and between triglyceride concentrations and vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression. Thus, acute hypertriglyceridemia generates triglyceride-rich HDL particles which have an impaired anti-inflammatory capacity.
Documentation centre