In recent years, a variety of lipoprotein assays have been developed that subfractionate lipoprotein particles according to properties of these particles (size, density, charge). It has been proposed that these lipoprotein assays could improve the assessment of cardiovascular disease risk and also guide lipid-lowering therapies. However, although used in specialized lipid clinics and research studies, the general utility of these assays in clinical practice remained to be proven. In this review, Dr. Mora briefly reviewed laboratory methods available in clinical practice and discussed the literature evaluating these methods. Current limitations to the widespread clinical application of these methods were also reviewed. Another review in favour of advanced lipoprotein testing was provided by Dr. Superko in Controversies in Cardiovascular Medicine.
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