This in vitro study was conducted to investigate the effect of resveratrol on the production of various adipokines by human adipose tissue. For that purpose, subcutaneous abdominal adipose tissue explants were obtained from 8 healthy participants (age=43.6 years; body mass index=25.3 kg/m2). Results showed that resveratrol in vitro altered gene expression and secretion of several adipokines from human adipose tissue by inducing potentially beneficial changes. For instance, gene expression of the inflammatory adipokines such as interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, IL-1β was reduced whereas adiponectin gene expression was increased. Thus, these results suggest an anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue in vitro. More studies will be necessary to better understand whether this could become a new approach for the treatment of the metabolic syndrome.
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