Among participants in the Atherosclerosis Risk in Communities study who had no history of diabetes or cardiovascular disease, neither isolated impaired fasting glucose nor isolated impaired glucose tolerance increased cardiovascular disease risk. Individuals with isolated impaired fasting glucose were more likely to smoke, drink alcohol, and have higher body mass index, waist circumference, LDL cholesterol, and fasting insulin, as well as lower HDL cholesterol, whereas those with isolated impaired glucose tolerance had higher triglycerides, systolic blood pressure, and white blood cell count.