This study was conducted to examine the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose and lipid metabolism. The cohort included 47 chronic coffee drinkers who abstained for one month from coffee drinking, thereafter they consumed 4 cups/day of filtered coffee in the second month and finally 8 cups/day of filtered coffee for the last month. Results showed that coffee consumption generated an increase in coffee-derived compounds, particularly serum caffeine, chlorogenic acid, and caffeic acid metabolites. Changes in some markers of inflammation and oxidative stress were also observed, and suggested an anti-inflammatory effect of coffee drinking. There was a significant decrease in circulating interleukin (IL)-18 concentrations and serum 8-isoprostane levels, but no changes in systemic C-reactive protein or IL-6 concentrations. They also observed a significant increase in adiponectin concentrations with coffee consumption. Moreover, beneficial effects on the lipid profile such as increases in HDL cholesterol, and apolipoprotein AI as well as decreases in LDL cholesterol/HDL cholesterol and apolipoprotein B/apolipoprotein AI ratios were observed. However, no effect of coffee consumption was reported on glucose metabolism. Thus, these findings suggest a positive impact of coffee consumption on some cardiometabolic risk markers.
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