The effect of exercise on endothelial function (assessed by brachial artery flow-mediated dilation FMD) after a high-fat meal was investigated in a sample of 8 healthy men. There was a significant decrease in brachial artery diameters after the high-fat meal in the control group and the single bout of continuous moderate-intensity exercise (CME) group with no change in the high-intensity interval exercise group (HIIE). Consequently, average peak shear rates increased in the control and CME groups and remained unchanged in the HIIE group. Moreover, following the high-fat meal, the total antioxidant status in the two exercise groups remained higher than in the control group. Finally, when the three groups were combined, there was a relationship between total antioxidant status and FMD. This study provides evidence that exercise has a beneficial impact on the vasculature that is exercise-intensity dependent and could be mediated by the exercise-induced antioxidant status.
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