This study assessed the effects of fructose (a potent stimulator of hepatic de novo lipogenesis) on intrahepatocellular lipids and insulin sensitivity in healthy offsprings of patients with type 2 diabetes (n=16 men and 8 controls). Higher intrahepatocellular lipids and triglycerides and lower whole-body insulin sensitivity were observed in offsprings compared to control subjects. The high-fructose diet significantly increased intrahepatocellular lipids, intramyocellular lipids, VLDL triglycerides and fasting hepatic glucose output. The effect of the fructose diet on VLDL triglyceride concentrations was greater in the offspring group than in controls. A diet rich in fructose increased ectopic lipid deposition in liver and muscle. Moreover, since healthy offsprings of patients with type 2 diabetes had higher VLDL triglyceride levels than the control group following the 7-day high-fructose diet, it is suggested that these individuals may be more prone to dyslipidemia in response to this type of diet.
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