Because body fat distribution is an important predictor of obesity-related complications, this study sought to investigate differences in VLDL-triglyceride (TG) production, VLDL-TG oxidation, and VLDL-TG storage in lean and obese women characterized by upper or lower obesity. Hepatic VLDL-TG production was higher in upper body obese women compared to lean women. VLDL-TG oxidation was similar between the three groups. In women with upper body obesity, more VLDL-TG was deposited in the upper subcutaneous fat compartment, whereas in lower body obese women, more VLDL-TG was deposited in femoral fat. Thus, the hypertriglyceridemic state observed in women with upper body obesity was caused by hepatic VLDL-TG overproduction without concomitant increased removal via oxidation and adipose tissue redeposition.
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