The purpose of this study was to examine the effects of acute hyperinsulinemia on VLDL1 and VLDL2 intestinal (apo B48) and hepatic (apo B100) lipoprotein production in six healthy men in a constant fed state by using the euglycemic-hyperinsulinemic clamp technique. Results revealed that insulin infusion suppressed both VLDL1 and VLDL2 apo B48 and apo B100 concentrations as a result of suppression of VLDL1 lipoprotein secretion, with consequently less VLDL2 formed from VLDL1. This study is the first to show that insulin acutely suppresses intestinal apo B48 containing lipoprotein production which is in part dependent on insulin-mediated suppression of plasma free fatty acids. These results indicate that insulin directly suppresses both intestinal and hepatic lipoprotein production in humans.
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