Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.

Proc Natl Acad Sci USA 1997;94:4171-5

Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U

Description

This report demonstrates that adipose cell expression of insulin receptor substrate-1 is reduced in type 2 diabetes, but not in type 1 diabetes, and is therefore associated with insulin resistance.

Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.

Proc Natl Acad Sci USA 1997;94:4171-5

Description

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