This study was conducted to examine the association between intrahepatic fat content and VLDL apolipoprotein (apo) B100 kinetics and the impact of a moderate weight loss on this relationship. Results showed that elevated liver fat content was predictive of VLDL apo B100 oversecretion, and that the reduction of liver fat with weight loss was significantly associated with a corresponding decrease in VLDL apo B100 secretion. It was also found that liver fat content was significantly associated with intra-abdominal (visceral) fat, insulin resistance, dietary fat intake, and the VLDL apo B100 concentrations and secretion rate. However, liver fat content was not associated with plasma concentrations of retinol-binding protein 4, fetuin A, adiponectin, interleukin-6, and tumor necrosis factor-alpha. These kinetic studies of VLDL apo B100 metabolism suggest an important role of liver fat in the dyslipidemia associated with abdominal obesity and the beneficial impact of weight loss observed on liver fat with the corresponding decrease in VLDL apo B100 secretion.
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