This study demonstrates that, in abdominal adipose tissue, adiponectin gene expression is directly related to the expression of its receptors. As well, intra-abdominal (visceral) adipose tissue has lower levels of adiponectin gene receptors mRNA, especially adiponectin receptor 2 (AdipoR2), compared to subcutaneous adipose tissue. This paper also shows that circulating adiponectin levels are related to adiponectin gene but not receptor expression. Other key findings of this study are that the expression of adiponectin gene and both receptors is reduced in association with obesity, but not diabetes, and that the adiponectin concentration in adipocytes is reduced in the intra-abdominal adipose tissue of obese individuals. Lastly, the authors conclude that severe obesity suppresses expression of adiponectin gene and its receptors in both abdominal fat depots (i.e., subcutaneous and intra-abdominal adipose tissue) and that expression levels in intra-abdominal adipose tissue are specifically linked to hyperinsulinemia and dyslipidemia.
Documentation centre