Reconstituted high-density lipoprotein increases plasma high-density lipoprotein anti-inflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes.

Description

This study examined the impact of reconstituted HDL infusions on HDL anti-inflammatory properties and ex vivo cholesterol efflux in 13 men with type 2 diabetes. Investigators found that 4 and 72 hours after the infusion, the anti-inflammatory properties of HDL increased in parallel to its concentration in plasma. Peripheral blood monocyte CD11b expression and neutrophil adhesion to a fibrinogen matrix were significantly reduced 72 hours post reconstituted HDL infusion compared to placebo. Furthermore, cholesterol efflux was significantly higher after reconstituted HDL infusion at 3 and 72 hours. Thus, in patients with type 2 diabetes, reconstituted HDL infusions have important and significant anti-inflammatory effects.