Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women.

Description

This cross-sectional study examined the associations between cardiometabolic risk variables, such as atherogenic dyslipidemia, the metabolic syndrome, and type 2 diabetes with sex hormone-binding globulin (SHBG) in a sample of 777 elderly men and women. Half of the sample had the metabolic syndrome (as per NCEP-ATP III modified clinical criteria). In both men and women, low SHBG levels were linked to high triglyceride-low HDL cholesterol dyslipidemia and the metabolic syndrome independent of waist circumference or insulin resistance as determined by the HOMA model. In women, low SHBG concentrations also increased the likelihood of hypertriglyceridemia and elevated apolipoprotein B levels. SHBG may thus represent one more marker of metabolic complications (atherogenic dyslipidemia of abdominal obesity), particularly in women.