The purpose of this study was to investigate the postprandial plasma and adipose tissue adiponectin changes in relation to obesity and type 2 diabetes. The study sample was composed of 10 patients with obesity and type 2 diabetes, 11 patients with obesity only and 11 normal-weight control subjects. The results revealed that adiponectin levels were acutely regulated by a fat-rich meal. After the meal, plasma adiponectin decreased in patients with type 2 diabetes, but increased in the two other groups. As for adiponectin gene expression, it was decreased in patients with type 2 diabetes, but was unchanged in obese subjects and the control group. Moreover, postprandial adiponectin levels were inversely correlated with triglyceride-rich lipoproteins, and directly with HDL cholesterol and adipose tissue lipoprotein lipase activity. The authors suggested that the reduced adiponectin levels found in type 2 diabetic patients could impair postprandial lipoprotein metabolism. Thus, these results suggest that type 2 diabetes is associated with lower postprandial plasma levels and adipose tissue gene expression of adiponectin independently of degree of adiposity and whole-body insulin resistance.
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