Very low density lipoprotein metabolism and plasma adiponectin as predictors of high-density lipoprotein apolipoprotein A-I kinetics in obese and nonobese men.

Description

In this paper, the associations between the fractional catabolic rate (FCR) of HDL apolipoprotein AI and VLDL kinetics, plasma adiponectin and serum amyloid A (SAA) concentrations were studied in a sample of 50 obese (body mass index >30 kg/m2) and 37 nonobese (body mass index ≤30 kg/m2) men. It was found that variation in VLDL apolipoprotein B production and thereby triglyceride concentrations had a major impact on the catabolism of HDL apolipoprotein AI. There was no association between SAA and HDL apolipoprotein AI in either obese or nonobese men. In a multivariate model, VLDL apolipoprotein B production rate and insulin resistance (determined by the HOMA model) contributed to the variation in HDL apolipoprotein AI catabolism in obese men, whereas VLDL apolipoprotein B production rate and adiponectin were predictors of HDL apolipoprotein AI catabolism in nonobese men. These results strengthen the need for lipid-regulating interventions that decrease plasma triglyceride-rich lipoprotein concentrations (reduction in VLDL apolipoprotein B production) in order to delay the catabolism of HDL apolipoprotein AI.